Dr. Nicholas Boyd Gibbins

Dr. Nicholas Boyd Gibbins (MEng, PhD)

Scientific Director – SC21: 

Dr. Nicholas is the Scientific Director for SC21 Group in Bangkok, Thailand. He is an experienced bioengineer specializing in, human iPS cell culture, neural organoids, cancer organoid modeling, tumor microenvironment, and CRISPR-Cas9 genome editing.

His placements included Queen Mary University in London, University College of London, and CiRA, Kyoto University, Japan – trained by noble prize winner Shinya Yamanaka.

Dr. Nicholas Boyd Gibbins (MEng, PhD)

Research Experience

Postdoctoral Research Fellow
(2017 – 2019)
Department of Clinical Application, CiRA, Kyoto University, Japan

Summary:

• Developing a high throughput 3D organoid culture screening system for Diffuse Intrinsic Pontine Glioma (DIPG) by CRISPR-Cas9 gene editing of human iPS cells to create cancer cell line models.
• Designed and performed CRISPR-Cas9 RNP knock-out and ssODN knock-in genome editing experiments to develop cancer models by electroporation.
• Differentiated iPS cells into neural stem cells, OPCs, neurons, oligodendrocytes, and glial cells, with desired brain regional specificity
• Optimized 3D organoid culture for 96-well plate format
• Established overexpression cell lines using the piggyBac transposon system.
• Supervised and lead project of full-time technician to strategically improve organoid system to incorporate key human cancer interactions of the tumor microenvironment.

Ph.D Student
(2013 – 2016)
Albert Lab, Ear Institute, University College London

• PhD Project focused on homeostasis and protein turnover in the auditory transducer complex of Drosophila melanogaster, as well as its molecular, cellular and system-level characterization, and functional genomic analysis of the mode of action of neuroactive insecticides.
• Established conditional gene regulation systems
• Characterized proteostasis / homeostasis in Drosophila hearing
• Succeeded in achieving adult hearing regeneration in deaf mutant background.
• Electrophysiology
• Functional genomic screening in collaboration with Syngenta for insecticide mode of action analysis.

Master’s student
(2011 – 2012, 8 months)

Master’s Group Project: The Design of an Ankle Rehabilitation Device, Queen Mary London

Group project to design a rehabilitation device for chronic ankle instability sufferers, specifically aiming to re-train vestibular control after proprioceptive disruption.
• Took a leadership role to organize group activities

DR.

NICHOLAS

RESUME

SUMMARY